Human Safety Organization

The Human Safety Organization employs scientists from diverse fields, including reproductive toxicology, immunology, respiratory toxicology, molecular biology, genotoxicity and carcinogenicity.  More recently, genomics is being applied in the various toxicological disciplines in line with the latest trends in the field.

P&G's researchers work closely with scientists at universities, governmental bodies and industry organizations to share knowledge and work collaboratively on new and improved methods and approaches to advance the science of toxicology.

The P&G scientists work at the leading edge of toxicology and human health risk assessment. They routinely publish their findings in the peer-reviewed scientific literature.

Additionally, their expertise in the area of human health risk assessment is regularly recognized:

• Society of Toxicology 2003 Award for the Enhancement of Animal Welfare - Dr. G. Frank Gerberick (P&G Beauty Science) and Dr. Ian Kimber (Syngenta).
• Society of Toxicology Award for the best developmental and reproductive toxicology paper published in Toxicological Sciences in 2002, for a paper by J. Naciff, L. Jump, S. Torontali, G. Carr, J. Tiesman, G. Overmann and G. Daston, "Gene Expression Profile Induced by 17-Alpha-Ethynyl Estradiol, Bisphenol A and Genistein in the Developing Female Reproductive System of the Rat."
• 2001 Outstanding Publication Award from the Ecological and Toxicological Association of Dyes and Organic Pigment Manufacturers for: Thresholds in Contact Sensitization: Theoretical and Practical Considerations, by I. Kimber, G.F. Gerberick (P&G Beauty Science) and D.A. Basketter, Food and Chemical Toxicology, vol 37: 553-560 (1999).
• SmithKline Beecham 2000 Laboratory Animal Welfare Prize, awarded by the Research Defense Society to Dr. G. Frank Gerberick (P&G Beauty Science), Dr. Ian Kimber (Syngenta) and Dr. David Basketter (Unilever) for the development and validation of the murine local lymph node assay.
• Humane Society of the United States, 1999 Russell and Burch Award, awarded to Dr. Katherine Stitzel for her work in developing and promoting alternative methods to the use of animals in product safety testing.

Our in-house research capabilities include:

• Capability for reproductive toxicity evaluation and research to develop in vitro Tests which are conducted ex-vivo - this can include studies within a test tube, on an artificial substrate e.g. artificial collagen or on a skin equivalent model created from skin cells. alternatives for reproductive toxicology
• Genomic assays applied in various fields of toxicology
• Genotoxicity assays
• Capability for assessment of skin irritation and sensitization and research to develop in vitro alternatives for these toxicological endpoints
• Clinical research
• Respiratory toxicology
• Mechanistic research
• Analytical chemistry support for the research efforts (GC/MS, LC/MS, MS/MS, RAD-TLC, RAD-LC, RAD-GC. LSC, combustion analysis)